Cancer antigens: immune recognition of self and altered self.
AN Houghton - The Journal of experimental medicine, 1994 - ncbi.nlm.nih.gov
AN Houghton
The Journal of experimental medicine, 1994•ncbi.nlm.nih.govA tacit assumption of cancer immunology has been that tumors express non-self or" foreign"
antigens. The recent identification of a handful of potentially immunogenic cancer antigens
shows that they are not truly foreign. Although the boundary between self and non-self is not
well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than
with the non-self paradigm for antigens recognized in infectious diseases.
antigens. The recent identification of a handful of potentially immunogenic cancer antigens
shows that they are not truly foreign. Although the boundary between self and non-self is not
well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than
with the non-self paradigm for antigens recognized in infectious diseases.
A tacit assumption of cancer immunology has been that tumors express non-self or" foreign" antigens. The recent identification of a handful of potentially immunogenic cancer antigens shows that they are not truly foreign. Although the boundary between self and non-self is not well-defined, this first look at cancer antigens fits more with a self/altered self paradigm than with the non-self paradigm for antigens recognized in infectious diseases.
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