IL-4 and IL-13 induce myofibroblastic phenotype of human lung fibroblasts through c-Jun NH2-terminal kinase–dependent pathway
S Hashimoto, Y Gon, I Takeshita, S Maruoka… - Journal of allergy and …, 2001 - Elsevier
Background: Myofibroblasts play a role in the airway remodeling response of bronchial
asthma. IL-4 and IL-13 are possibly involved in the airway remodeling response by inducing
extracellular matrix production by fibroblasts. However, the roles of these cytokines in
inducing the phenotypic modulation of human lung fibroblasts (HLFs) to myofibroblasts and
the intracellular signal have not been determined. Objective: We examined the effect of IL-4
and IL-13 on inducing the phenotypic modulation of HLFs to myofibroblasts characterized by …
asthma. IL-4 and IL-13 are possibly involved in the airway remodeling response by inducing
extracellular matrix production by fibroblasts. However, the roles of these cytokines in
inducing the phenotypic modulation of human lung fibroblasts (HLFs) to myofibroblasts and
the intracellular signal have not been determined. Objective: We examined the effect of IL-4
and IL-13 on inducing the phenotypic modulation of HLFs to myofibroblasts characterized by …