[HTML][HTML] Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts
V Solomon, AL Goldberg - Journal of Biological Chemistry, 1996 - ASBMB
Recent studies have suggested that activation of the ubiquitin-proteasome pathway is
primarily responsible for the rapid loss of muscle proteins in various types of atrophy. The
present studies were undertaken to test if different classes of muscle proteins are degraded
by this pathway. In extracts of rabbit psoas muscle, the complete degradation of soluble
proteins to amino acids was stimulated up to 6-fold by ATP. Peptide aldehyde inhibitors of
the proteasome or the removal of proteasomes markedly inhibited only the ATP-dependent …
primarily responsible for the rapid loss of muscle proteins in various types of atrophy. The
present studies were undertaken to test if different classes of muscle proteins are degraded
by this pathway. In extracts of rabbit psoas muscle, the complete degradation of soluble
proteins to amino acids was stimulated up to 6-fold by ATP. Peptide aldehyde inhibitors of
the proteasome or the removal of proteasomes markedly inhibited only the ATP-dependent …