[HTML][HTML] Glucose-stimulated preproinsulin gene expression and nucleartrans-location of pancreatic duodenum homeobox-1 require activation of phosphatidylinositol 3 …
I Rafiq, G da Silva Xavier, S Hooper… - Journal of Biological …, 2000 - ASBMB
Exposure of islet β-cells to elevated glucose concentrations (30 versus 3 mm) prompts
enhanced preproinsulin (PPI) gene transcription and thetrans-location to the nucleoplasm of
pancreaticduodenum homeobox-1 (PDX-1; Rafiq, I., Kennedy, H., and Rutter, GA (1998) J.
Biol. Chem. 273, 23241–23247). Here, we show that in MIN6 β-cells, over-expression of
p110. CAAX, a constitutively active form of phosphatidylinositol 3-kinase (PI3K) mimicked
the activatory effects of glucose on PPI promoter activity, whereas Δp85, a dominant …
enhanced preproinsulin (PPI) gene transcription and thetrans-location to the nucleoplasm of
pancreaticduodenum homeobox-1 (PDX-1; Rafiq, I., Kennedy, H., and Rutter, GA (1998) J.
Biol. Chem. 273, 23241–23247). Here, we show that in MIN6 β-cells, over-expression of
p110. CAAX, a constitutively active form of phosphatidylinositol 3-kinase (PI3K) mimicked
the activatory effects of glucose on PPI promoter activity, whereas Δp85, a dominant …