Nutrient–secretion coupling in the pancreatic islet β-cell: recent advances

GA Rutter - Molecular aspects of medicine, 2001 - Elsevier
Insulin secretion from pancreatic islet β-cells is a tightly regulated process, under the close
control of blood glucose concentrations, and several hormones and neurotransmitters.
Defects in glucose-triggered insulin secretion are ultimately responsible for the development
of type II diabetes, a condition in which the total β-cell mass is essentially unaltered, but β-
cells become progressively “glucose blind” and unable to meet the enhanced demand for
insulin resulting for peripheral insulin resistance. At present, the mechanisms by which …