[HTML][HTML] Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus
A Varrault, B Bilanges, DJG Mackay, E Basyuk… - Journal of Biological …, 2001 - ASBMB
ZAC is a recently isolated zinc finger protein that induces apoptosis and cellcycle arrest. The
corresponding gene is imprinted maternally through an unknown mechanism and maps to
6q24–q25, within the minimal interval harboring the gene responsible for transient neonatal
diabetes mellitus (TNDM) and a tumor suppressor gene involved in breast cancer. Because
of its functional properties, imprinting status, and expression pattern in mammary cell lines
and tumors, ZAC is the best candidate so far for both disease conditions. In the present work …
corresponding gene is imprinted maternally through an unknown mechanism and maps to
6q24–q25, within the minimal interval harboring the gene responsible for transient neonatal
diabetes mellitus (TNDM) and a tumor suppressor gene involved in breast cancer. Because
of its functional properties, imprinting status, and expression pattern in mammary cell lines
and tumors, ZAC is the best candidate so far for both disease conditions. In the present work …