[HTML][HTML] Pattern of recruitment of immunoregulatory antigen-presenting cells in malignant melanoma
JR Lee, RR Dalton, JL Messina, MD Sharma… - Laboratory …, 2003 - Elsevier
The mechanism by which the immune system of a tumor-bearing host acquires tolerance
toward tumor antigens is still elusive. Antigen-presenting cells (APCs) are critical regulators
of the decision between immune response and tolerance. APCs that express the tryptophan-
degrading enzyme indoleamine 2, 3-dioxygenase (IDO) have been found to inhibit T-cell
responses both in vitro and in vivo. We hypothesized that malignant tumors exploit this
mechanism by recruiting IDO-expressing APCs to the tumor-draining lymph nodes. To test …
toward tumor antigens is still elusive. Antigen-presenting cells (APCs) are critical regulators
of the decision between immune response and tolerance. APCs that express the tryptophan-
degrading enzyme indoleamine 2, 3-dioxygenase (IDO) have been found to inhibit T-cell
responses both in vitro and in vivo. We hypothesized that malignant tumors exploit this
mechanism by recruiting IDO-expressing APCs to the tumor-draining lymph nodes. To test …