Interferon-γ inducible exchanges of 20S proteasome active site subunits: why?
M Groettrup, S Khan, K Schwarz, G Schmidtke - Biochimie, 2001 - Elsevier
When cells are stimulated with the cytokines IFN-γ or TNF-α, the synthesis of three
proteasome subunits LMP2 (β1i), LMP7 (β5i), and MECL-1 (β2i) is induced. These subunits
replace the three subunits delta (β1), MB1 (β5), and Z (β2), which bear the catalytically
active sites of the proteasome, during proteasome neosynthesis. The cytokine-induced
exchanges of three active site subunits of a complex protease is unprecedented in biology
and one may expect a strong functional driving force for this system to evolve. These …
proteasome subunits LMP2 (β1i), LMP7 (β5i), and MECL-1 (β2i) is induced. These subunits
replace the three subunits delta (β1), MB1 (β5), and Z (β2), which bear the catalytically
active sites of the proteasome, during proteasome neosynthesis. The cytokine-induced
exchanges of three active site subunits of a complex protease is unprecedented in biology
and one may expect a strong functional driving force for this system to evolve. These …