Association of Hepatitis C Virus—Specific CD8+ T Cells with Viral Clearance in Acute Hepatitis C

NH Grüner, TJ Gerlach, MC Jung… - The Journal of …, 2000 - academic.oup.com
NH Grüner, TJ Gerlach, MC Jung, HM Diepolder, CA Schirren, WW Schraut, R Hoffmann…
The Journal of infectious diseases, 2000academic.oup.com
CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for
acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the
outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were
studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked
immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The
highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with …
Abstract
CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)—specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers of IFN-γ—producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P < .001). Our data show that the number of IFN—γ-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection.
Oxford University Press