[HTML][HTML] Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-κB ligand (RANKL)
M Matsumoto, T Sudo, T Saito, H Osada… - Journal of Biological …, 2000 - ASBMB
The receptor activator of NF-κB ligand (RANKL) induces osteoclast differentiation from bone
marrow cells in the presence of macrophage colony-stimulating factor. We found that
treatment of bone marrow cells with SB203580 inhibited osteoclast differentiation via
inhibition of the RANKL-mediated signaling pathway. To elucidate the role of p38 mitogen-
activated protein (MAP) kinase pathway in osteoclastogenesis, we employed RAW264 cells
which could differentiate into osteoclast-like cells following treatment with RANKL. In a dose …
marrow cells in the presence of macrophage colony-stimulating factor. We found that
treatment of bone marrow cells with SB203580 inhibited osteoclast differentiation via
inhibition of the RANKL-mediated signaling pathway. To elucidate the role of p38 mitogen-
activated protein (MAP) kinase pathway in osteoclastogenesis, we employed RAW264 cells
which could differentiate into osteoclast-like cells following treatment with RANKL. In a dose …