[HTML][HTML] β-Cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
L Härndahl, N Wierup, S Enerbäck, H Mulder… - Journal of Biological …, 2004 - ASBMB
The second messenger cAMP mediates potentiation of glucose-stimulated insulin release.
Use of inhibitors of cAMP-hydrolyzing phosphodiesterase (PDE) 3 and overexpression of
PDE3B in vitro have demonstrated a regulatory role for this enzyme in insulin secretion. In
this work, the physiological significance of PDE3B-mediated degradation of cAMP for the
regulation of insulin secretion in vivo and glucose homeostasis was investigated in
transgenic mice overexpressing PDE3B in pancreatic β-cells. A 2-fold overexpression of …
Use of inhibitors of cAMP-hydrolyzing phosphodiesterase (PDE) 3 and overexpression of
PDE3B in vitro have demonstrated a regulatory role for this enzyme in insulin secretion. In
this work, the physiological significance of PDE3B-mediated degradation of cAMP for the
regulation of insulin secretion in vivo and glucose homeostasis was investigated in
transgenic mice overexpressing PDE3B in pancreatic β-cells. A 2-fold overexpression of …