[HTML][HTML] Fibrillin degradation by matrix metalloproteinases: identification of amino-and carboxy-terminal cleavage sites
VJ Hindson, JL Ashworth, MJ Rock, S Cunliffe… - FEBS letters, 1999 - Elsevier
VJ Hindson, JL Ashworth, MJ Rock, S Cunliffe, CA Shuttleworth, CM Kielty
FEBS letters, 1999•ElsevierFibrillin molecules form the structural framework of elastic fibrillin-rich microfibrils of the
extracellular matrix. We have investigated the proteolysis of recombinant fibrillin molecules
by five matrix metalloproteinases. Cleavage sites were defined at the carboxy-terminal end
of the fibrillin-1 proline-rich region and the corresponding fibrillin-2 glycine-rich region (exon
10), and within exon 49 towards the carboxy-terminus of fibrillin-1. Cleavage at these sites is
predicted to disrupt the structure and function of the fibrillin-rich microfibrils.
extracellular matrix. We have investigated the proteolysis of recombinant fibrillin molecules
by five matrix metalloproteinases. Cleavage sites were defined at the carboxy-terminal end
of the fibrillin-1 proline-rich region and the corresponding fibrillin-2 glycine-rich region (exon
10), and within exon 49 towards the carboxy-terminus of fibrillin-1. Cleavage at these sites is
predicted to disrupt the structure and function of the fibrillin-rich microfibrils.
Fibrillin molecules form the structural framework of elastic fibrillin-rich microfibrils of the extracellular matrix. We have investigated the proteolysis of recombinant fibrillin molecules by five matrix metalloproteinases. Cleavage sites were defined at the carboxy-terminal end of the fibrillin-1 proline-rich region and the corresponding fibrillin-2 glycine-rich region (exon 10), and within exon 49 towards the carboxy-terminus of fibrillin-1. Cleavage at these sites is predicted to disrupt the structure and function of the fibrillin-rich microfibrils.
Elsevier