[HTML][HTML] The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
LGD Fryer, A Parbu-Patel, D Carling - Journal of Biological Chemistry, 2002 - ASBMB
AMP-activated protein kinase (AMPK) is activated within the cell in response to multiple
stresses that increase the intracellular AMP: ATP ratio. Here we show that incubation of
muscle cells with the thiazolidinedione, rosiglitazone, leads to a dramatic increase in this
ratio with the concomitant activation of AMPK. This finding raises the possibility that a
number of the beneficial effects of the thiazolidinediones could be mediated via activation of
AMPK. Furthermore, we show that in addition to the classical activation pathway, AMPK can …
stresses that increase the intracellular AMP: ATP ratio. Here we show that incubation of
muscle cells with the thiazolidinedione, rosiglitazone, leads to a dramatic increase in this
ratio with the concomitant activation of AMPK. This finding raises the possibility that a
number of the beneficial effects of the thiazolidinediones could be mediated via activation of
AMPK. Furthermore, we show that in addition to the classical activation pathway, AMPK can …