The endocytic pathway: a mosaic of domains
J Gruenberg - Nature reviews Molecular cell biology, 2001 - nature.com
Nature reviews Molecular cell biology, 2001•nature.com
Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within
the plane of the membrane, or of protein complexes associated with specific membrane
lipids. Whereas some of these molecular assemblies can be found in more than one
compartment, a given combination seems to be unique to each compartment, indicating that
membrane organization might be modular.
regions. These regions consist, at least in part, of specialized protein–lipid domains within
the plane of the membrane, or of protein complexes associated with specific membrane
lipids. Whereas some of these molecular assemblies can be found in more than one
compartment, a given combination seems to be unique to each compartment, indicating that
membrane organization might be modular.
Abstract
Organelles in the endocytic pathway are composed of a mosaic of structural and functional regions. These regions consist, at least in part, of specialized protein–lipid domains within the plane of the membrane, or of protein complexes associated with specific membrane lipids. Whereas some of these molecular assemblies can be found in more than one compartment, a given combination seems to be unique to each compartment, indicating that membrane organization might be modular.
nature.com