[PDF][PDF] Structures of staurosporine bound to CDK2 and cAPK–new tools for structure-based design of protein kinase inhibitors
LM Toledo, NB Lydon - Structure, 1997 - cell.com
LM Toledo, NB Lydon
Structure, 1997•cell.comProtein kinases are involved in a wide variety of signal transduction processes; their
deregulation has been implicated in a number of human diseases, including cancer and
disorders of the immune system. The recently determined structures of two protein kinases,
cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of
inhibitor–kinase interactions and inhibitor selectivity.
deregulation has been implicated in a number of human diseases, including cancer and
disorders of the immune system. The recently determined structures of two protein kinases,
cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of
inhibitor–kinase interactions and inhibitor selectivity.
Abstract
Protein kinases are involved in a wide variety of signal transduction processes; their deregulation has been implicated in a number of human diseases, including cancer and disorders of the immune system. The recently determined structures of two protein kinases, cAPK and CDK2, in complex with an inhibitor, staurosporine, provide a detailed account of inhibitor–kinase interactions and inhibitor selectivity.
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