Chromosomal Radiosensitivity During G2 Phase and Susceptibility to Plasmacytoma Induction in Mice
KK Sanford, R Parshad, M Potter, GM Jones… - Mechanisms in B-Cell …, 1986 - Springer
KK Sanford, R Parshad, M Potter, GM Jones, RP Nordan, SE Brust, FM Price
Mechanisms in B-Cell Neoplasia: Workshop at the National Cancer Institute …, 1986•SpringerGenetic differences in susceptibility to plasmacytoma induction among inbred strains of mice
are well documented. Whether induced by ip implantation of plastic discs or injection of
pristane, the BALB/c mouse, in contrast to most other commonly used inbred strains, is
significantly more susceptible (Merwin and Redmon, 1963; Morse et al., 1980; Potter et al.,
1984). The F 1 hybrid between BALB/c and a resistant strain such as DBA/2 is resistant. This
and other findings on hybrid crosses suggest that specific genes for susceptibility and/or …
are well documented. Whether induced by ip implantation of plastic discs or injection of
pristane, the BALB/c mouse, in contrast to most other commonly used inbred strains, is
significantly more susceptible (Merwin and Redmon, 1963; Morse et al., 1980; Potter et al.,
1984). The F 1 hybrid between BALB/c and a resistant strain such as DBA/2 is resistant. This
and other findings on hybrid crosses suggest that specific genes for susceptibility and/or …
Abstract
Genetic differences in susceptibility to plasmacytoma induction among inbred strains of mice are well documented. Whether induced by i. p. implantation of plastic discs or injection of pristane, the BALB/c mouse, in contrast to most other commonly used inbred strains, is significantly more susceptible (Merwin and Redmon, 1963; Morse et al., 1980; Potter et al., 1984). The F1 hybrid between BALB/c and a resistant strain such as DBA/2 is resistant. This and other findings on hybrid crosses suggest that specific genes for susceptibility and/or resistance determine tumor incidence (Potter et al., 1975; Potter and Wax, 1981). Studies are in progress to identify these genes through the development of congenic BALB/c sublines carrying genes from a resistant strain. Particularly useful in this endeavor is the BALB/cJ mouse, which was separated in 1937 from the BALB/cAn subline; although showing minimal genetic drift in most properties, the BALB/cJ mouse is resistant to plasmacytoma induction (Potter and Wax, 1981, 1985).
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