Coxsackievirus B3 from an infectious cDNA copy of the genome is cardiovirulent in mice
S Tracy, NM Chapman, Z Tu - Archives of virology, 1992 - Springer
S Tracy, NM Chapman, Z Tu
Archives of virology, 1992•SpringerSummary A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells,
produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post
inoculation (pi). Liver and serum are cleared of CVB3 by day 8 pi, but CVB3 persists in the
heart through day 14. The nucleotide sequence and the predicted amino acid sequence of
this clone have sites of divergence from 2 other completely sequenced CVB3 genomes
although overall identity of the three CVB3 genomes is 99%.
produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post
inoculation (pi). Liver and serum are cleared of CVB3 by day 8 pi, but CVB3 persists in the
heart through day 14. The nucleotide sequence and the predicted amino acid sequence of
this clone have sites of divergence from 2 other completely sequenced CVB3 genomes
although overall identity of the three CVB3 genomes is 99%.
Summary
A coxsackievirus B3 (CVB3) cDNA clone, upon transfection of HeLa cells, produces CVB3 capable of induction of cardiac inflammation in C3H/He mice by day 8 post inoculation (p.i.). Liver and serum are cleared of CVB3 by day 8 p.i., but CVB3 persists in the heart through day 14. The nucleotide sequence and the predicted amino acid sequence of this clone have sites of divergence from 2 other completely sequenced CVB3 genomes although overall identity of the three CVB3 genomes is 99%.
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