[HTML][HTML] Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its …

B Neufeld, A Grosse-Wilde, A Hoffmeyer… - Journal of Biological …, 2000 - ASBMB
In the search for physiological substrates of MAPK-activated protein (MAPKAP) kinases, we
identified the basic helix-loop-helix (bHLH) transcription factor E47 as an interaction partner
of chromosome 3p kinase (3pK) and MAPKAP-K2 (MK2). The E2A protein E47 is known to
be involved in the regulation of tissue-specific gene expression and cell differentiation. E47
is a phosphoprotein, and we identified 3pK and MK2 as E47 kinases in vitro. Furthermore,
the expression of either kinase results in a repression of the transcriptional activity of E47 on …