Lymphoma induction by human B cells in scid mice.
A Amadori, ML Veronese, MR Mazza, R Zamarchi… - Leukemia, 1992 - europepmc.org
A Amadori, ML Veronese, MR Mazza, R Zamarchi, M Mion, E D'Andrea, C Menin…
Leukemia, 1992•europepmc.orgLymphoma development was studied in scid mice injected ip with PBMC from EBV-positive
donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after
the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the
injected cell populations prevented lymphoma development in all mice, suggesting that T-
cell-derived factors are involved in the expansion of the latently EBV-infected B-cell
population within the immunodeficient host.
donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after
the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the
injected cell populations prevented lymphoma development in all mice, suggesting that T-
cell-derived factors are involved in the expansion of the latently EBV-infected B-cell
population within the immunodeficient host.
Lymphoma development was studied in scid mice injected ip with PBMC from EBV-positive donors. Most injected mice developed oligo/monoclonal B-cell tumors within 4 months after the inoculation; EBV genome was found in tumor cells. Removal of T lymphocytes from the injected cell populations prevented lymphoma development in all mice, suggesting that T-cell-derived factors are involved in the expansion of the latently EBV-infected B-cell population within the immunodeficient host.
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