Receptor for advanced glycation end products on human synovial fibroblasts: role in the pathogenesis of dialysis-related amyloidosis
FF Hou, JP Jiang, JQ Guo, GB Wang… - Journal of the …, 2002 - journals.lww.com
An important component of amyloid fibrils in dialysis-related amyloidosis (DRA) is β 2-
microglobulin (β 2 m) modified with advanced glycation end products (AGE). The amyloid
deposits are located principally in joint structures, with adjacent chronic inflammatory
reaction characterized by monocyte infiltration. This study examined the interaction of AGE-β
2 m with human synovial fibroblasts and investigated the proinflammatory effects of that
interaction. It was demonstrated that human synovial fibroblasts constitutively expressed the …
microglobulin (β 2 m) modified with advanced glycation end products (AGE). The amyloid
deposits are located principally in joint structures, with adjacent chronic inflammatory
reaction characterized by monocyte infiltration. This study examined the interaction of AGE-β
2 m with human synovial fibroblasts and investigated the proinflammatory effects of that
interaction. It was demonstrated that human synovial fibroblasts constitutively expressed the …