Caveolins, liquid-ordered domains, and signal transduction

EJ Smart, GA Graf, MA McNiven… - … and cellular biology, 1999 - Taylor & Francis
EJ Smart, GA Graf, MA McNiven, WC Sessa, JA Engelman, PE Scherer, T Okamoto…
Molecular and cellular biology, 1999Taylor & Francis
Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane
in endothelial and epithelial cells (14). Prior to the development of biochemical methods for
their purification, caveolae were thought to principally mediate the transcellular movement of
molecules (101, 145). Recently, the development of novel purification procedures has
greatly expanded our knowledge regarding the putative functions of caveolae in vivo. In this
review, we seek to update the working definition of caveolae, describe the functional roles of …
Caveolae were originally identified as ffask-shaped invaginations of the plasma membrane in endothelial and epithelial cells (14). Prior to the development of biochemical methods for their purification, caveolae were thought to principally mediate the transcellular movement of molecules (101, 145). Recently, the development of novel purification procedures has greatly expanded our knowledge regarding the putative functions of caveolae in vivo. In this review, we seek to update the working definition of caveolae, describe the functional roles of the caveolin gene family, and summarize the evidence that supports a role for caveolae as mediators of a number of cellular signaling processes.
OVERVIEW: CAVEOLAE AND CAVEOLA-RELATED DOMAINS ARE LIQUID-ORDERED MICRODOMAINS
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