[HTML][HTML] Infection, mimics, and autoimmune disease
NR Rose - The Journal of clinical investigation, 2001 - Am Soc Clin Investig
The Journal of clinical investigation, 2001•Am Soc Clin Investig
An infectious agent contributes to the induction of autoimmunity in two ways. First, it provides
a cognate, antigen-specific signal by molecular mimicry or by mobilizing endogenous
antigen (red arrows). In parallel, it causes inflammation, generating antigen nonspecific
signals (blue arrows) that potentiate immune responses through what is known as an
adjuvant effect.
a cognate, antigen-specific signal by molecular mimicry or by mobilizing endogenous
antigen (red arrows). In parallel, it causes inflammation, generating antigen nonspecific
signals (blue arrows) that potentiate immune responses through what is known as an
adjuvant effect.
An infectious agent contributes to the induction of autoimmunity in two ways. First, it provides a cognate, antigen-specific signal by molecular mimicry or by mobilizing endogenous antigen (red arrows). In parallel, it causes inflammation, generating antigen nonspecific signals (blue arrows) that potentiate immune responses through what is known as an adjuvant effect.
The Journal of Clinical Investigation