Bile acids suppress the secretion of very-low-density lipoprotein by human hepatocytes in primary culture
Y Lin, R Havinga, HJ Verkade, H Moshage… - Hepatology, 1996 - journals.lww.com
The existence of a relationship between bile acid and triacylglycerol metabolism in humans
has been established, but the underlying mechanism and its physiological relevance have
remained unclear. We have studied the effects of bile acids on the secretion of very-low-
density lipoprotein (VLDL)-associated triacylglycerol, using [3 H] glycerol labeling technique,
and apolipoprotein B (apoB) in human hepatocytes in primary culture. Human hepatocytes
secrete nascent VLDL with an average diameter of about 40 nm. Lipid composition of the …
has been established, but the underlying mechanism and its physiological relevance have
remained unclear. We have studied the effects of bile acids on the secretion of very-low-
density lipoprotein (VLDL)-associated triacylglycerol, using [3 H] glycerol labeling technique,
and apolipoprotein B (apoB) in human hepatocytes in primary culture. Human hepatocytes
secrete nascent VLDL with an average diameter of about 40 nm. Lipid composition of the …