[HTML][HTML] Phosphorylation and desensitization of the human β1-adrenergic receptor: involvement of G protein-coupled receptor kinases and cAMP-dependent protein …
NJ Freedman, SB Liggett, DE Drachman, G Pei… - Journal of Biological …, 1995 - ASBMB
Persistent stimulation of the β 1-adrenergic receptor (β 1 AR) engenders, within minutes,
diminished responsiveness of the β 1 AR/adenylyl cyclase signal transduction system. This
desensitization remains incompletely defined mechanistically, however. We therefore tested
the hypothesis that agonist-induced desensitization of the β 1 AR (like that of the related β 2
AR) involves phosphorylation of the receptor itself, by cAMP-dependent protein kinase
(PKA) and the β-adrenergic receptor kinase (βARK1) or other G protein-coupled receptor …
diminished responsiveness of the β 1 AR/adenylyl cyclase signal transduction system. This
desensitization remains incompletely defined mechanistically, however. We therefore tested
the hypothesis that agonist-induced desensitization of the β 1 AR (like that of the related β 2
AR) involves phosphorylation of the receptor itself, by cAMP-dependent protein kinase
(PKA) and the β-adrenergic receptor kinase (βARK1) or other G protein-coupled receptor …