Asymmetrical reductions of hippocampal NMDAR1 glutamate receptor mRNA in the psychoses
AJ Law, JFW Deakin - Neuroreport, 2001 - journals.lww.com
The psychotomimetic properties of NMDA glutamate receptor antagonists suggest there may
be disease related changes of this receptor in schizophrenia. Using in situ hybridisation
histochemistry (ISHH), we measured mRNA for the obligatory NMDAR1 subunit of the
NMDA glutamate receptor in post-mortem samples of hippocampus from schizophrenics,
depressives, bipolar patients and normal controls. A significant main effect of diagnosis was
observed in the dentate gyrus (ANOVA, p= 0.004) and a trend in the CA3 region (ANOVA, p …
be disease related changes of this receptor in schizophrenia. Using in situ hybridisation
histochemistry (ISHH), we measured mRNA for the obligatory NMDAR1 subunit of the
NMDA glutamate receptor in post-mortem samples of hippocampus from schizophrenics,
depressives, bipolar patients and normal controls. A significant main effect of diagnosis was
observed in the dentate gyrus (ANOVA, p= 0.004) and a trend in the CA3 region (ANOVA, p …