Decreased expression of mRNAs encoding non-NMDA glutamate receptors GluRl and GluR2 in medial temporal lobe neurons in schizophrenia
SL Eastwood, B McDonald, PWJ Burnet… - Molecular brain …, 1995 - Elsevier
Schizophrenia is associated with a complex pattern of alterations in the glutamatergic
system of the brain. Previous studies have shown a reduced density of some hippocampal
non-N-methyl-d-aspartate (non-NMDA) receptors which is accompanied by a loss of
encoding receptor mRNA. We have extended this work using in situ hybridization
histochemistry with oligonucleotide probes specific for two non-NMDA receptor transcripts,
GluRl and GluR2, in right and left medial temporal lobe sections from 9 schizophrenics and …
system of the brain. Previous studies have shown a reduced density of some hippocampal
non-N-methyl-d-aspartate (non-NMDA) receptors which is accompanied by a loss of
encoding receptor mRNA. We have extended this work using in situ hybridization
histochemistry with oligonucleotide probes specific for two non-NMDA receptor transcripts,
GluRl and GluR2, in right and left medial temporal lobe sections from 9 schizophrenics and …