Surgically implantable long-term antipsychotic delivery systems for the treatment of schizophrenia

SJ Siegel, KI Winey, RE Gur, RH Lenox… - …, 2002 - Elsevier
Non-adherence with medication remains a major correctable cause for poor outcome in
schizophrenia. We describe a surgically implantable preparation of haloperidol with the aim
that patients will have superior outcomes with improved medication adherence from
implants. In contrast to depot formulations, implantable pellets could last many months,
providing symptomatic improvement for periods of time never before possible. Additionally,
in the event of unacceptable side effects, implants could be removed, offering a degree of …