Effect of capsaicin and resiniferatoxin on peptidergic neurons in cultured dorsal root ganglion
S Jeftinija, F Liu, K Jeftinija, L Urban - Regulatory peptides, 1992 - Elsevier
The neurotoxic effect of capsaicin has been shown to be selective on a subpopulation of
small dorsal root ganglion neurons in newborn animals. The aim of this study was to provide
evidence of the long lasting effect of capsaicin and its ultrapotent analog resiniferatoxin
(RTX) on sensory peptidergic neurons maintained in organotypic cultures. The effects of the
two irritants were examined on neurons that contained substance P (SP) and calcitonin
gene-related peptide (CGRP). Exposure of the cultures to 10 μM capsaicin and 100 nM RTX …
small dorsal root ganglion neurons in newborn animals. The aim of this study was to provide
evidence of the long lasting effect of capsaicin and its ultrapotent analog resiniferatoxin
(RTX) on sensory peptidergic neurons maintained in organotypic cultures. The effects of the
two irritants were examined on neurons that contained substance P (SP) and calcitonin
gene-related peptide (CGRP). Exposure of the cultures to 10 μM capsaicin and 100 nM RTX …