[HTML][HTML] p21Cip-1/SDI-1/WAF-1 gene is involved in chondrogenic differentiation of ATDC5 cells in vitro
Y Negishi, N Ui, M Nakajima, K Kawashima… - Journal of Biological …, 2001 - ASBMB
Development of skeletal cartilage is characterized with coupling growth arrest and cell
differentiation. Here, to understand the cyclin-dependent kinase inhibitors involved in the
progression of chondrogenic differentiation, we examined changes in the expression levels
of cyclin-dependent kinase inhibitor members using mouse ATDC5 prechondrocytes as a
widely used in vitro model of cartilage differentiation. Up-regulation of p21 andp27 mRNA
was observed following a decrease in growth rate of prechondrocytes, and both transcripts …
differentiation. Here, to understand the cyclin-dependent kinase inhibitors involved in the
progression of chondrogenic differentiation, we examined changes in the expression levels
of cyclin-dependent kinase inhibitor members using mouse ATDC5 prechondrocytes as a
widely used in vitro model of cartilage differentiation. Up-regulation of p21 andp27 mRNA
was observed following a decrease in growth rate of prechondrocytes, and both transcripts …