[HTML][HTML] Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils
S Gardai, BB Whitlock, C Helgason, D Ambruso… - Journal of Biological …, 2002 - ASBMB
Neutrophils undergo rapid spontaneous apoptosis. Multiple antiapoptotic stimuli can inhibit
this process via activation of the Akt pathway. However, despite no such effect singly,
combined anti-and proapoptotic stimuli inhibit Akt activity, leaving the cells susceptible to
accelerated apoptosis. The blockade of Akt activation depended on reduced
phosphoinositide 3, 4, 5-trisphosphate levels but not decreased phosphatidylinositol 3-
kinase activity, thus implicating the involvement of an inositol phosphatase. Evidence for …
this process via activation of the Akt pathway. However, despite no such effect singly,
combined anti-and proapoptotic stimuli inhibit Akt activity, leaving the cells susceptible to
accelerated apoptosis. The blockade of Akt activation depended on reduced
phosphoinositide 3, 4, 5-trisphosphate levels but not decreased phosphatidylinositol 3-
kinase activity, thus implicating the involvement of an inositol phosphatase. Evidence for …