Caspases: enemies within
NA Thornberry, Y Lazebnik - Science, 1998 - science.org
NA Thornberry, Y Lazebnik
Science, 1998•science.orgREVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized
machinery. The central component of this machinery is a proteolytic system involving a
family of proteases called caspases. These enzymes participate in a cascade that is
triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins,
resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to
the ability to rationally manipulate apoptosis for therapeutic gain.
machinery. The central component of this machinery is a proteolytic system involving a
family of proteases called caspases. These enzymes participate in a cascade that is
triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins,
resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to
the ability to rationally manipulate apoptosis for therapeutic gain.
REVIEW
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.
AAAS