[HTML][HTML] TLR4 and MD-2 expression is regulated by immune-mediated signals in human intestinal epithelial cells
MT Abreu, ET Arnold, LS Thomas, R Gonsky… - Journal of Biological …, 2002 - ASBMB
The normal intestinal epithelium is not inflamed despite contact with a high density of
commensal bacteria. Intestinal epithelial cells (IEC) express low levels of TLR4 and MD-2
and are lipopolysaccharide (LPS)-unresponsive. We hypothesized that immune-mediated
signals regulate the expression of TLR4 and MD-2 in IEC. Expression of TLR4 and MD-2
was examined in normal colonic epithelial cells or intestinal epithelial cell lines. The effect of
the cytokines interferon (IFN)-γ, IFN-α, and tumor necrosis factor-α (TNF-α) on TLR4 and MD …
commensal bacteria. Intestinal epithelial cells (IEC) express low levels of TLR4 and MD-2
and are lipopolysaccharide (LPS)-unresponsive. We hypothesized that immune-mediated
signals regulate the expression of TLR4 and MD-2 in IEC. Expression of TLR4 and MD-2
was examined in normal colonic epithelial cells or intestinal epithelial cell lines. The effect of
the cytokines interferon (IFN)-γ, IFN-α, and tumor necrosis factor-α (TNF-α) on TLR4 and MD …