[HTML][HTML] DNA binding and transcriptional activation by a PDX1· PBX1b· MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex
Y Liu, RJ MacDonald, GH Swift - Journal of Biological Chemistry, 2001 - ASBMB
In pancreatic acinar cells, the HOX-like factor PDX1 acts as part of a trimeric complex with
two TALE class homeodomain factors, PBX1b and MEIS2b. The complex binds to
overlapping half-sites for PDX1 and PBX. The trimeric complex activates transcription in
cells to a level about an order of magnitude greater than PDX1 alone. The N-terminal PDX1
activation domain is required for detectable transcriptional activity of the complex, even
though PDX1 truncations bearing only the PDX1 C-terminal homeodomain and …
two TALE class homeodomain factors, PBX1b and MEIS2b. The complex binds to
overlapping half-sites for PDX1 and PBX. The trimeric complex activates transcription in
cells to a level about an order of magnitude greater than PDX1 alone. The N-terminal PDX1
activation domain is required for detectable transcriptional activity of the complex, even
though PDX1 truncations bearing only the PDX1 C-terminal homeodomain and …