[HTML][HTML] Disruption of adiponectin causes insulin resistance and neointimal formation
N Kubota, Y Terauchi, T Yamauchi, T Kubota… - Journal of Biological …, 2002 - ASBMB
The adipocyte-derived hormone adiponectin has been proposed to play important roles in
the regulation of energy homeostasis and insulin sensitivity, and it has been reported to
exhibit putative antiatherogenic properties in vitro. In this study we generated adiponectin-
deficient mice to directly investigate whether adiponectin has a physiological protective role
against diabetes and atherosclerosis in vivo. Heterozygous adiponectin-deficient (adipo+/−)
mice showed mild insulin resistance, while homozygous adiponectin-deficient (adipo−/−) …
the regulation of energy homeostasis and insulin sensitivity, and it has been reported to
exhibit putative antiatherogenic properties in vitro. In this study we generated adiponectin-
deficient mice to directly investigate whether adiponectin has a physiological protective role
against diabetes and atherosclerosis in vivo. Heterozygous adiponectin-deficient (adipo+/−)
mice showed mild insulin resistance, while homozygous adiponectin-deficient (adipo−/−) …