[HTML][HTML] Phosphoinositide 3-kinase activity is necessary for insulin-dependent inhibition of apolipoprotein B secretion by rat hepatocytes and localizes to the …
TL Phung, A Roncone, KL de Mesy Jensen… - Journal of Biological …, 1997 - ASBMB
Insulin inhibits apolipoprotein B (apoB) secretion by primary rat hepatocytes through
activation of phosphoinositide 3-kinase (PI 3-K). Current studies demonstrate that the PI 3-K
inhibitor wortmannin inhibits both basal and insulin-stimulated PI 3-K activities. Wortmannin
and LY 294002, two structurally distinct PI 3-K inhibitors, prevent insulin-dependent
inhibition of apoB secretion in a dose-dependent manner. To link PI 3-K activation to insulin
action on apoB, we investigated whether insulin induced localization of activated PI 3-K to …
activation of phosphoinositide 3-kinase (PI 3-K). Current studies demonstrate that the PI 3-K
inhibitor wortmannin inhibits both basal and insulin-stimulated PI 3-K activities. Wortmannin
and LY 294002, two structurally distinct PI 3-K inhibitors, prevent insulin-dependent
inhibition of apoB secretion in a dose-dependent manner. To link PI 3-K activation to insulin
action on apoB, we investigated whether insulin induced localization of activated PI 3-K to …