[HTML][HTML] Oxidative events cause degradation of apoB-100 but not of apo [a] and facilitate enzymatic cleavage of both proteins
C Edelstein, K Nakajima, D Pfaffinger… - Journal of Lipid Research, 2001 - ASBMB
Abstract Lipoprotein [a](Lp [a]) contains equimolar amounts of apoB-100 and apolipoprotein
[a](apo [a]). Both proteins are amenable to degradation in vivo by mechanisms yet to be
clearly defined. In this study, we examined the in vitro susceptibility of LDL and Lp [a],
obtained from the same donor, to oxidation by either Cu 2+ or the combined Crotalus
adamanteus phospholipase A 2 and soybean lipoxygenase system, monitoring the course
of the reaction by the generation of conjugated dienes and fatty acids. In some experiments …
[a](apo [a]). Both proteins are amenable to degradation in vivo by mechanisms yet to be
clearly defined. In this study, we examined the in vitro susceptibility of LDL and Lp [a],
obtained from the same donor, to oxidation by either Cu 2+ or the combined Crotalus
adamanteus phospholipase A 2 and soybean lipoxygenase system, monitoring the course
of the reaction by the generation of conjugated dienes and fatty acids. In some experiments …