[HTML][HTML] Apolipoprotein E is resistant to intracellular degradation in vitro and in vivo: evidence for retroendocytosis
PCN Rensen, MC Jong, LC van Vark… - Journal of biological …, 2000 - ASBMB
Apolipoprotein E (apoE) is an important determinant for the uptake of triglyceride-rich
lipoproteins and emulsions by the liver, but the intracellular pathway of apoE following
particle internalization is poorly defined. In the present study, we investigated whether
retroendocytosis is a unique feature of apoE as compared with apoB by studying the
intracellular fate of very low density lipoprotein-sized apoE-containing triglyceride-rich
emulsion particles and LDL after LDLr-mediated uptake. Incubation of HepG2 cells with [3 H] …
lipoproteins and emulsions by the liver, but the intracellular pathway of apoE following
particle internalization is poorly defined. In the present study, we investigated whether
retroendocytosis is a unique feature of apoE as compared with apoB by studying the
intracellular fate of very low density lipoprotein-sized apoE-containing triglyceride-rich
emulsion particles and LDL after LDLr-mediated uptake. Incubation of HepG2 cells with [3 H] …