[HTML][HTML] Regulation of calcium signalling by docosahexaenoic acid in human T-cells: implication of CRAC channels
A Bonin, NA Khan - Journal of Lipid Research, 2000 - ASBMB
We elucidated the role of docosahexaenoic acid (DHA) on the increases in free intracellular
calcium concentrations,[Ca 2+] i, in human (Jurkat) T-cell lines. DHA evoked an increase in
[Ca 2+] i in a dose-dependent manner in these cells. Anti-CD3 antibody, known to stimulate
increases in Ca 2+ from endoplasmic reticulum (ER) via the production of inositol
trisphosphate, also evoked increases in [Ca 2+] i in Jurkat T-cells. We also used
thapsigargin which inhibits Ca 2+-ATPase of the ER and, therefore, increases Ca 2+ in the …
calcium concentrations,[Ca 2+] i, in human (Jurkat) T-cell lines. DHA evoked an increase in
[Ca 2+] i in a dose-dependent manner in these cells. Anti-CD3 antibody, known to stimulate
increases in Ca 2+ from endoplasmic reticulum (ER) via the production of inositol
trisphosphate, also evoked increases in [Ca 2+] i in Jurkat T-cells. We also used
thapsigargin which inhibits Ca 2+-ATPase of the ER and, therefore, increases Ca 2+ in the …