Identification in 2 Independent Samples of a Novel Schizophrenia RiskHaplotype of the Dystrobrevin Binding Protein Gene (DTNBP1)
NM Williams, A Preece, DW Morris… - Archives of general …, 2004 - jamanetwork.com
Context Recent research suggests that variation in the gene encoding dystrobrevin binding
protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype
has been identified in more than 1 study. Objectives To confirmDTNBP1as a schizophrenia
susceptibility gene, to identify and replicate specific risk and protective haplotypes, and to
explore relationships betweenDTNBP1and the phenotype. Design Genetic association
study based on mutation detection and case-control analysis. Setting All subjects were …
protein (DTNBP1) confers susceptibility to schizophrenia. Thus far, no specific risk haplotype
has been identified in more than 1 study. Objectives To confirmDTNBP1as a schizophrenia
susceptibility gene, to identify and replicate specific risk and protective haplotypes, and to
explore relationships betweenDTNBP1and the phenotype. Design Genetic association
study based on mutation detection and case-control analysis. Setting All subjects were …