Animal models of human disease Experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease
RH Swanborg - Clinical immunology and immunopathology, 1995 - Elsevier
The cause of multiple sclerosis (MS) is unknown, but the pathology is consistent with an
immunological etiology. Studies conducted with the animal model of MS, experimental
autoimmune encephalomyelitis (EAE), have provided insight into how the immune system
can provoke an immunopathological response characteristic of that seen in MS. The use of
inbred rats and mice for studies of EAE has been especially rewarding with respect to the
identification of the epitopes of encephalitogenic antigens responsible for the induction of …
immunological etiology. Studies conducted with the animal model of MS, experimental
autoimmune encephalomyelitis (EAE), have provided insight into how the immune system
can provoke an immunopathological response characteristic of that seen in MS. The use of
inbred rats and mice for studies of EAE has been especially rewarding with respect to the
identification of the epitopes of encephalitogenic antigens responsible for the induction of …