Failure of elevated heat shock protein 70 antibodies to alter cochlear function in mice
DR Trune, JB Kempton, CR Mitchell, SH Hefeneider - Hearing research, 1998 - Elsevier
Heat shock protein 70 (HSP70) has been suggested as the putative cochlear antigen
underlying a proposed autoimmune etiology in certain cases of Meniere's disease and
idiopathic hearing loss. To determine if antibodies to this cellular protein are capable of
altering cochlear function, BALB/c (N= 3) and CBA/J (N= 9) mice were inoculated with
bovine HSP70 by intraperitoneal injections (10 μg in saline) every 10 days for 7 or 10
months, respectively. An equal number of control mice were injected with PBS according to …
underlying a proposed autoimmune etiology in certain cases of Meniere's disease and
idiopathic hearing loss. To determine if antibodies to this cellular protein are capable of
altering cochlear function, BALB/c (N= 3) and CBA/J (N= 9) mice were inoculated with
bovine HSP70 by intraperitoneal injections (10 μg in saline) every 10 days for 7 or 10
months, respectively. An equal number of control mice were injected with PBS according to …