Central antinociceptive effects of cannabinoids have been well documented. However,
relatively little is known about the peripheral effects of the cannabinoids on inflammation. In
the present study, we evaluated the effects of peripherally administered cannabinoids on
three indices of inflammation: carrageenan-induced thermal hyperalgesia, carrageenan-
induced edema, and capsaicin-induced plasma extravasation. In addition, we determined
the effect of cannabinoids on capsaicin-evoked neuropeptide release from isolated rat …