Randomized comparison of quinine-clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy

R McGready, T Cho, L Villegas, A Brockman… - Transactions of the …, 2001 - Elsevier
In areas where multidrug-resistant Plasmodium falciparum (MDR-Pf) is prevalent, only
quinine is known to be safe and effective in pregnant women. On the western border of
Thailand, 7 days of supervised quinine (30 mg/kg daily) cures two-thirds of P. falciparum-
infected women in the 2nd and 3rd trimesters of pregnancy. Artesunate is effective against
MDR-Pf and the limited data on its use in pregnancy suggest it is safe. An open randomized
comparison of supervised quinine (10 mg salt/kg every 8 h) in combination with clindamycin …