Effects of chronic excess salt ingestion: evidence that genetic factors play an important role in susceptibility to experimental hypertension

LK Dahl, M Heine, L Tassinari - The Journal of experimental …, 1962 - ncbi.nlm.nih.gov
LK Dahl, M Heine, L Tassinari
The Journal of experimental medicine, 1962ncbi.nlm.nih.gov
Using the genetic technique of selective inbreeding, it has been possible to quickly develop
two statistically separable populations from one unselected strain of Sprague-Dawley rats.
One of these is very sensitive, the other very resistant, to the development of experimental
hypertension from a high salt diet. It was suggested that similar genetic factors operate in
man.
Abstract
Using the genetic technique of selective inbreeding, it has been possible to quickly develop two statistically separable populations from one unselected strain of Sprague-Dawley rats. One of these is very sensitive, the other very resistant, to the development of experimental hypertension from a high salt diet. It was suggested that similar genetic factors operate in man.
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