[11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
A Gerhard, RB Banati, GB Goerres, A Cagnin, R Myers… - Neurology, 2003 - AAN Enterprises
Neurology, 2003•AAN Enterprises
Microglia, the brain's intrinsic macrophages, bind (R)-PK11195 when activated by neuronal
injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in
patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was
primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia
nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an
indicator of disease activity,[11C](R)-PK11195 PET can thus be used to characterize the in …
injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in
patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was
primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia
nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an
indicator of disease activity,[11C](R)-PK11195 PET can thus be used to characterize the in …
Microglia, the brain’s intrinsic macrophages, bind (R)-PK11195 when activated by neuronal injury. The authors used [11C](R)-PK11195 PET to localize in vivo microglial activation in patients with multiple system atrophy (MSA). Increased [11C](R)-PK11195 binding was primarily found in the dorsolateral prefrontal cortex, putamen, pallidum, pons, and substantia nigra, reflecting the known distribution of neuropathologic changes in MSA. Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA.
American Academy of Neurology