New testing strategy to detect early HIV-1 infection for use in incidence estimates and for clinical and prevention purposes
RS Janssen, GA Satten, SL Stramer, BD Rawal… - Jama, 1998 - jamanetwork.com
Context.—Differentiating individuals with early human immunodeficiency virus 1 (HIV-1)
infection from those infected for longer periods is difficult but important for estimating HIV
incidence and for purposes of clinical care and prevention. Objective.—To develop and
validate a serologic testing algorithm in which HIV-1–positive persons with reactive test
results on a sensitive HIV-1 enzyme immunoassay (EIA) but nonreactive results on a less
sensitive (LS) EIA are identified as having early infection. Design.—Diagnostic test and …
infection from those infected for longer periods is difficult but important for estimating HIV
incidence and for purposes of clinical care and prevention. Objective.—To develop and
validate a serologic testing algorithm in which HIV-1–positive persons with reactive test
results on a sensitive HIV-1 enzyme immunoassay (EIA) but nonreactive results on a less
sensitive (LS) EIA are identified as having early infection. Design.—Diagnostic test and …