[HTML][HTML] Insulin-like growth factor-I induces renal cell hypertrophy via a calcineurin-dependent mechanism
JL Gooch, Y Tang, JM Ricono, HE Abboud - Journal of Biological Chemistry, 2001 - ASBMB
Insulin-like growth factor-I (IGF-I) may play an important role in the development of renal
hypertrophy. In this study we determined the effect of IGF-I on cultured mesangial cells
(MCs) and examined activation of key signaling pathways. IGF-I induced hypertrophy as
determined by an increase in cell size and an increase in protein to DNA ratio and increased
accumulation of extracellular matrix (ECM) proteins. IGF-I also activated both Erk1/Erk2
MAPK and phosphatidylinositol 3-kinase (PI3K) in MCs. Inhibition of either MAPK or PI3K …
hypertrophy. In this study we determined the effect of IGF-I on cultured mesangial cells
(MCs) and examined activation of key signaling pathways. IGF-I induced hypertrophy as
determined by an increase in cell size and an increase in protein to DNA ratio and increased
accumulation of extracellular matrix (ECM) proteins. IGF-I also activated both Erk1/Erk2
MAPK and phosphatidylinositol 3-kinase (PI3K) in MCs. Inhibition of either MAPK or PI3K …