Regulation of Bone Formation and Vision by LRP5
MS Patel, G Karsenty - New England Journal of Medicine, 2002 - Mass Medical Soc
New England Journal of Medicine, 2002•Mass Medical Soc
Osteoporosis affects several million people and is associated with medical costs of up to $15
billion per year in the United States alone. 1, 2 Thus, identifying the molecular mechanisms
that control bone mass is a task of the utmost importance. The recent identification of the role
of the low-density lipoprotein receptor–related protein 5 (LRP5) gene in the regulation of
bone mass is a landmark discovery. 3–6 We examine the lock-and-key mechanism involving
LRP5 that regulates two different functions: bone formation and vision. The Lock The low …
billion per year in the United States alone. 1, 2 Thus, identifying the molecular mechanisms
that control bone mass is a task of the utmost importance. The recent identification of the role
of the low-density lipoprotein receptor–related protein 5 (LRP5) gene in the regulation of
bone mass is a landmark discovery. 3–6 We examine the lock-and-key mechanism involving
LRP5 that regulates two different functions: bone formation and vision. The Lock The low …
Osteoporosis affects several million people and is associated with medical costs of up to $15 billion per year in the United States alone.1,2 Thus, identifying the molecular mechanisms that control bone mass is a task of the utmost importance. The recent identification of the role of the low-density lipoprotein receptor–related protein 5 (LRP5) gene in the regulation of bone mass is a landmark discovery.3–6 We examine the lock-and-key mechanism involving LRP5 that regulates two different functions: bone formation and vision.
The Lock
The low-density lipoprotein receptor–related proteins are a family of cell-surface receptors involved in diverse biologic processes, . . .
The New England Journal Of Medicine