Injury and development in polycystic kidney disease

JP Calvet - Current opinion in nephrology and hypertension, 1994 - journals.lww.com
JP Calvet
Current opinion in nephrology and hypertension, 1994journals.lww.com
The large diversity of genetic and nongenetic causes of polycystic kidney disease begs the
question of whether there is a common denominator in the process of cyst formation.
Accumulating evidence now indicates that cysts are made up of immature epithelium, which
suggests that cystic transformation may be caused by an arrested developmental process
that locks cells in a unique differentiated state. Although there may be any number of
possible causes of this cystic change, it is proposed that one unifying mechanism may be …
Abstract
The large diversity of genetic and nongenetic causes of polycystic kidney disease begs the question of whether there is a common denominator in the process of cyst formation. Accumulating evidence now indicates that cysts are made up of immature epithelium, which suggests that cystic transformation may be caused by an arrested developmental process that locks cells in a unique differentiated state. Although there may be any number of possible causes of this cystic change, it is proposed that one unifying mechanism may be subcritical injury-induced cellular dedifferentiation.
Lippincott Williams & Wilkins