Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes
MJ Sampson, IR Davies, S Braschi, K Ivory, DA Hughes - Atherosclerosis, 2003 - Elsevier
Uptake of modified low density lipoprotein (LDL) by monocyte-macrophages is mediated by
the scavenger receptor CD36, which is upregulated in vitro by high glucose concentrations
and oxidatively modified LDL. We hypothesised that monocyte CD36 expression would be
higher in Type 2 diabetes, and would increase during acute hyperglycaemia. Sixteen
subjects with Type 2 diabetes and 11 controls underwent a 75 g oral glucose load.
Monocyte CD36 expression (by laser flow cytometry), plasma LDL diene conjugates, plasma …
the scavenger receptor CD36, which is upregulated in vitro by high glucose concentrations
and oxidatively modified LDL. We hypothesised that monocyte CD36 expression would be
higher in Type 2 diabetes, and would increase during acute hyperglycaemia. Sixteen
subjects with Type 2 diabetes and 11 controls underwent a 75 g oral glucose load.
Monocyte CD36 expression (by laser flow cytometry), plasma LDL diene conjugates, plasma …